Research and Clinical Trials

COG ARAR0331: Treatment of Childhood Nasopharyngeal Carcinoma with Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy
Brief Description  
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as amifostine, may protect normal cells from the side effects of radiation therapy. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with amifostine and chemotherapy may kill more tumor cells.
Who may be Eligible  

  • Histological diagnosis of nasopharyngeal carcinoma WHO type II or III
    • Stage I-IV disease
    • Newly diagnosed disease
  • Up to 18 years
  • Not pregnant or nursing :
  • No prior chemotherapy or radiotherapy to the nasopharynx or neck for the treatment of nasopharyngeal carcinoma
IRB Number  
Principal Investigator  
Kaplan, Joel

For More Information, Contact  Lynnae  , Schwandt
Phone:  (704) 355-1188  Fax:  (704) 446-1989  
Address:1025 Morehead Medical Drive Suite 600 Charlotte, NC 28204