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If your injury or condition isn’t improving with traditional orthopedic treatments like physical therapy or cortisone injections, orthobiologics may be a promising alternative. Orthobiologics are substances derived from your own body or other natural sources that enhance natural healing processes. They are used to promote healing and regeneration of musculoskeletal tissues, including bones, joints and muscles.

At Atrium Health Musculoskeletal Institute, we offer several types of orthobiologic treatments to help you get back to the activities you love. Our orthopedic and sports medicine specialists thoroughly evaluate your condition and develop a tailored treatment plan that’s best for you, including follow-up appointments and post-treatment rehabilitation.

Conditions treated

We treat the following conditions and injuries:

  • Ankle arthritis and cartilage defect
  • Ankle sprain/ligament injury
  • Biceps tendonitis
  • Elbow pain and problems
  • Frozen shoulder
  • Glenohumeral arthritis
  • Greater trochanteric bursitis/gluteus medius tendinopathy
  • Hamstring injuries
  • Hip problems
  • Knee osteoarthritis and chondromalacia
  • Knee problems
  • Lateral epicondylitis (tennis elbow)
  • Medial epicondylitis (golfer's elbow)
  • Partial/low-grade ulnar collateral ligament (UCL) injuries
  • Partial or interstitial rotator cuff injuries (or tendinopathy)
  • Patellar tendonitis (jumper's knee)
  • Patellar/quadriceps tendinopathy
  • Plantar fasciitis
  • Quadriceps tendonitis
  • Shoulder labral tear/SLAP (superior labrum anterior to posterior) tear
  • Shoulder tendonitis
  • Tendinitis
  • Tendinosis

Orthobiologic treatments


Platelet-rich plasma therapy

Platelet-rich plasma (PRP) therapy is increasingly used to treat injuries in ligaments, tendons and cartilage. Additionally, it is proving effective in addressing osteoarthritis in various joints like the hip, knee and shoulder.


Adipose-derived cell therapy uses fat collected from your body (lipoaspirate), which contains a high concentration of important cells called mesenchymal stromal cells (MSC) alongside various growth factors. Under certain conditions, these cells have the potential to generate new tissue like bone, cartilage, fat and blood vessels.

Fat can be collected from numerous areas of the body through a procedure similar to liposuction, most commonly from the abdominal wall or the back of the hip/gluteal region.

Bone marrow aspirate concentrate

Bone marrow concentrate (BMC), also known as bone marrow aspirate concentrate (BMAC), is a fluid containing cells taken from bone marrow, including mesenchymal stem cells (MSCs). Bone marrow is the soft, spongy substance that fills the inner cavities of bones. It is where blood is produced.

Tiny spaces in the bone marrow hold blood and stem cells, the primitive cells that are able to grow into various types of cells. Under certain conditions, some of these cells can also create new tissue like bone, cartilage, fat and blood vessels.



Physicians Who Specialize in Orthobiologics

For a list of all sports medicine providers, visit here.

Frequently Asked Questions