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Paul G. Thomes, PhD

Research Scientist
Liver Pathobiology Laboratory
James G. Cannon Research Center

Prior Positions and Experience

Associate Professor, Department of Biology, University of North Carolina at Charlotte (Charlotte, NC)

Assistant Professor, Department of Biology, University of North Carolina at Charlotte (Charlotte, NC)

Research Assistant Professor, Department of Biology, University of North Carolina at Charlotte (Charlotte, NC)

Research Analyst, Department of General Surgery, University of North Carolina at Chapel Hill (Chapel Hill, NC)

Postdoctoral Fellow, NIH National Research Service Award, Department of Medicine, University of North Carolina at Chapel Hill (Chapel Hill, NC)


BS (Summa Cum Laude): 1988, North Carolina State University (Raleigh, NC)
PhD: 1993, North Carolina State University (Raleigh, NC)

Recent Publications

Sendi H, Mehrab-Mohseni M, Foureau DM, Ghosh S, Walling TL, Steuerwald N, Zamor PJ, Kaplan KJ, Jacobs C, Ahrens WA, Russo MW, CLemens MG, Schrum LW, Bonkovsky HL. MiR-122 decreases HCV entry into hepatocytes through binding to the 3' UTR of OCLN mRNA. Liver Int. 2015;35(4):1315-23. PMID: 25302477

Li T, Eheim AL, Klein S, Uschner FE, Smith AC, Brandon-Warner E, Ghosh S, Bonkovsky HL, Trebicka J, Schrum LW. Novel role of nuclear receptor Rev-erbα in hepatic stellate cell activitation: potential therapeutic target for liver injury. Hepatology. 2014;59(6):2283-96. PMID: 24497272

Bonkovsky HL, Hou W, Steuerwald N, Tian Q, Li T, Parsons J, Hamilton A, Hwang S, Schrum L. Heme status affects human hepatic messenger RNA and microRNAs expression. World J Gastroenterol. 2013;19:1593-1601. [PMID: 23538684]

Ghosh S, Kaplan KJ, Schrum LW, Bonkovsky HL. Cytoskeletal proteins: shaping progression of hepatitis C virus-induced liver disease. Int Rev Cell Mol Biol. 2013;302:279-319. [PMID: 23351713]

Lakner AM, Steuerwald NM, Schrum LW. Reply to HEP-12-0853.R3. Hepatology. 2013;57:1286-7. See article

Brandon-Warner E, Schrum LW, Schmidt CM, McKillop IH. Rodent models of alcoholic liver disease: Of mice and men. Alcohol. 2012;46:715-25. [PMID: 22960051]

Brandon-Warner E, Eheim AL, Foureau DM, Walling TL, Schrum LW, McKillop IH. Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice. Cancer Lett. 2012;326:88-95. [PMID: 22863537]

Brandon-Warner E, Walling TL, Schrum LW, McKillop IH. Chronic ethanol feeding accelerates hepatocellular carcinoma progression in a sex-dependent manner in a mouse model of hepatocarcinogenesis. Alcohol Clin Exp Res. 2012;36:641-53. [PMID: 22017344]

Hou W, Tian Q, Steuerwald NM, Schrum LW, Bonkovsky HL. The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes. Biochim Biophys Acta. 2012;1819:1113-22. [PMID: 22698995]

Lakner AM, Steuerwald N, Walling T, Ghosh S, McKillop IH, Russo MW, Bonkovsky HB, Schrum LW. Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis. Hepatology. 2012;56:300-10. [PMID: 22278637]

Osna N, Kharbanda K, Schrum L, Dolganiuc A. Advances in alcoholic liver disease. Int J Hepatol. 2012:563018. See article

Lakner AM, Walling TL, McKillop IH, Schrum LW. Altered aquaporin expression and role in apoptosis during hepatic stellate cell activation. Liv. Int. 2011 Jan;31(1):42-51. [PMID: 20958918]

Day SA*, Lakner AM*, Moore CC, Yen MH, Clemens MG, Wu ES, Schrum LW. Opioid-like compound exerts anti-fibrotic activity via decreased hepatic stellate cell activation and inflammation. Biochem Pharmacol. 2011;81(8):996-1003. [PMID: 21291870] *Both authors contributed equally to this manuscript

Thompson KJ, Lakner AM, Cross BW, Tsukada S, Rippe RA, McKillop IH, Schrum LW. S-adenosyl-L-methionine inhibits collagen secretion in hepatic stellate cells via increased ubiquitination. Liver Int. 2011;31:891-901. [PMID: 21645221]

Mehrab-Mohseni M, Sendi H, Steuerwald N, Ghosh S, Schrum LW, Bonkovsky HL. Legalon-SIL downregulates HCV core and NS5A in human hepatocytes expressing full-length HCV. World J Gastroenterol. 2011;17:1694-1700. [PMID: 21483629]

Tian Q, Li T, Hou W, Zheng J, Schrum LW, Bonkovsky HL. Lon Peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells. J. Biol. Chem. 2011;286:26424-30. [PMID: 21659532]

Moore CC, Lakner AM, Yengo CM and Schrum LW. Identification and function of nonmuscle myosin II isoforms in hepatic stellate cells. World J Hepatol. 2011;3:184-97. [PMCID: PMC3158907]

Sokolov E, Schrum LW, McKillop IH. Altered expression and function of regulator of G-protein signaling-17 (RGS17) in hepatocellular carcinoma. Cell Signal. 2011;23:1603-10. [PMID: 21620966]

Lakner AM, Bonkovsky HL, Schrum LW. microRNAs: fad or future of liver disease. World J Gastroenterol. 2011;17:2536-42. [PMID: 21633658]

Thompson KJ, McKillop IH, Schrum LW. Targeting collagen expression in alcoholic liver disease. World J Gastroenterol. 2011;17:2473-81. [PMCID: PMC3103805]

Ghosh S, Ahrens WA, Phatak SU, Hwang S, Schrum LW, Bonkovsky HL. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J Viral Hepat. 2011;18:e568-77. [PMID: 21914078]

Hwang SI, Lee YY, Park JO, Norton HJ, Clemens E, Schrum LW, Bonkovsky HL. Effects of a single dose of oral iron on hepcidin concentrations in human urine and serum analyzed by an improved LC-MS/MS method. Clinica Chemica Acta. 2011;412:2241-7. [PMID: 21867695]

Ellefson WM, Lakner AM, Hamilton A, McKillop IH, Bonkovsky HL, Steuerwald NM, Huet YM, Schrum LW. Neonatal androgenization exacerbates alcohol-induced liver injury in adult rats, an effect abrogated by estrogen. PLoS ONE. 2011;6(12):e29463. [PMID: 22206017]

Brandon-Warner E, Sugg JA, Schrum LW, McKillop IH. Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in rat hepatocellular carcinoma cells. Cancer Lett. 2010;291(1):120-9. [PMID: 19900758]

Lakner AM, Moore CC, Gulledge AA, Schrum LW. 2010. Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation. World J Gastroenterol. 2010;16(40):5047-56. [PMCID: PMC2965281]

McKillop IH, Schrum LW. Role of Alcohol in Liver Carcinogenesis. Semin. Liver Dis. 2009;29(2):222-32. [PMID: 19387921]

Son G, Hines IN, Lindquist J, Schrum LW, Rippe RA. Inhibition of Phosphatidylinositol 3-Kinase Signaling in Hepatic Stellate Cells Blocks the Progression of Hepatic Fibrosis. Hepatology. 2009;50(5):1512-23. [PMID: 19790269]

Karaa A*, Thompson KJ*, McKillop IH, Clemens MG, Schrum LW. S-Adenosyl-L-Methionine (SAMe) Attenuates Oxidative Stress and Hepatic Stellate Cell Activation in an Ethanol-Lipopolysaccharide (LPS)-Induced Fibrotic Rat Model. Shock. 2008;30:197-205. [PMID: 18180699] *Both authors contributed equally to this manuscript

Zheng J, Tian Q, Hou W, Watts JA, Schrum LW, Bonkovsky HL. Tissue-specific Expression of ALA Synthase-1 and Heme Oxygenase-1 and Their Expression in Livers of Rats Chronically Exposed to Ethanol. FEBS Lett. 2008;582(13):1829-34. [PMID: 18472004]

Current, Recent and Pending Grant Support

Tenascin-C as a therapeutic target and biomarker for obesity-induced HCC
Funding Agency: Atrium Health
Role: Co-Principal investigator (David Sindram)
Years: 01/01/14-12/31/14
Goal: To delineate the cellular mechanism of tenascin-C in obesity-induced HCC

Role of microRNAs in HSC-mediated fibrogenesis
Funding Agency: NIH/NIAAA - R21
Role: Principal Investigator
Years: 12/01/2013 - 11/30/2015
Goal: To determine the role of miR19b in HSC-mediated fibrosis and test this miR as an effective anti-fibrotic molecule