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Research Summary

Research conducted at the Oral Medicine Research Laboratory uses metagenomics and genome-wide functional genomic approaches to investigate the molecular biomarkers in the oral cavity for both oral and systemic diseases. We have characterized the oral microbial composition in pneumonia, cancer chemotherapy, and bacteremia following dental manipulations. We have also determined the human genes involved in mucositis following chemotherapy in multiple cancers. We are currently studying the oral biomarkers of disease in head and neck cancer, infective endocarditis, Sjogren’s syndrome, and mucositis following conditioning regimens prior to hematopoietic stem cell transplant. We are using bioinformatics software/computational systems biology tools to investigate microbial community interactions, human gene interactions and drug effects in the oral cavity.

Our laboratory is also involved in genomic analysis of multi-drug resistant bacterial pathogens involved in health care associated infections as part of the collaborative effort with Dickson Analytics (DA2) and Department of Infection Control and Prevention.

The laboratory serves both internal and external collaborators. I lab operates under BSL-2 containment and practices, and is equipped with essential molecular microbiology equipment and state-of-the-art bioinformatics software/ computational systems biology tools. The research team is composed of researchers, clinicians, research nurses and other staff with expertise in molecular biology, microbiology, bioinformatics, biostatistics, epidemiology, oral medicine, hospital-based dentistry and clinical trials.

Oral Medicine Research Team

  • Farah K. B. Mougeot, PhD
  • Jean-Luc C. Mougeot, PhD
  • Michael T. Brennan, DDS
  • Peter B. Lockhart , DDS
  • Darla Morton
  • Craig B. Stevens
  • Jenene Noll
  • James Davis

Contact Information

Farah B. Mougeot, PhD
Associate Professor
Director, Microbiome Research
Oral Medicine Research Laboratory
Atrium Health
1000 Blythe Blvd
Charlotte, NC 28232

Email:farah.mougeot@atriumhealth.org
Phone: 704-355-8132


Farah K. Bahrani Mougeot, PhD

Director, Microbiome Research
Oral Medicine Research Laboratory
Carolinas Medical Center
Associate Professor and Associate Graduate Faculty, UNC-Charlotte


Prior Positions and Experience

  • 2012- Director, Microbiome Research- Oral Medicine Research Laboratory, CMC (Charlotte, NC)
  • 2007-2012 Molecular Microbiology Scientist, LBP, Cannon Research Center, CMC (Charlotte, NC)
  • 2002-2007 Senior Scientist, Director, Oral Medicine Research Laboratory, CMC (Charlotte, NC)
  • 2000-2002 Senior Scientist/ Group leader, Prokaria, Ltd. (Reykjavik, Iceland)
  • 1999-2000 NIAID/National research Service Award (NRSA) Fellowship in Vaccinology (Bethesda, MD)
  • 1998 Certificate in Epidemiology of Pediatric Infectious Diseases, WHO (Geneva, Switzerland)
  • 1997-2000 Research Fellow/ Bacterial Pathogenesis, Division of Infectious Diseases & Center for Vaccine Development, University of Maryland (Baltimore, MD)
  • 1995-1996 European Molecular Biology Organization (EMBO) Fellowship in Cellular Microbiology (Heidelberg, Germany)
  • 1995-1997 Postdoctoral Fellow, Pathogen-Host Interaction, Pasteur Institute (Paris, France)
  • 1989-1995 Research Assistant and Postdoctoral Fellow/ Bacterial Pathogenesis, School of Medicine, University of Maryland (Baltimore, Maryland)
  • 1987-1989 Research and Teaching Assistant, University of North Carolina at Charlotte (Charlotte, NC)

Education

PhD: 1994 School of Medicine, University of Maryland (Baltimore, MD)

Research Interests

For over 27 years, Dr. Mougeot’s research has revolved around understanding of the mechanisms of pathogenesis of bacteria in infectious diseases. The results of some of her previous studies have laid the groundwork for ongoing vaccine development against common uropathogens including Proteus mirabilis and uropathogenic E. coli, the design of anti-pathogenicity molecules against the enteric bacterial pathogens such as Shigella flexneri, the identification of diverse and novel bacterial pathogens involved in systemic infections such as pneumonia caused by the bacterial colonizers of the oral cavity, and characterization of the bacteremia following dental procedures.

Using molecular-based strategies, Dr. Mougeot studies the bacteria involved in disease in their human niche. Her current work at the Department of Oral Medicine at CMC includes the characterization of the oral microbiome and the host factors and their impact in various diseases such as cancer, cardiovascular disease, and mucositis following chemotherapy.

Dr. Mougeot has also been involved in epidemiological studies of health care associated infections caused by Clostridium difficile and carbapenemase producing Enterobacteriaceae in collaboration with Departments of Infection Control and Internal Medicine/ Division of Gastroenterology at CMC.

Selected Recent Publications and Book Chapters

Hobel, C.F.V., Hreggvidsson, G.O., Marteinsson, V.T., Bahrani-Mougeot, F.K., Einarsson, F.M., Kristjansson, J.K. Cloning, expression and characterization of a highly thermostable family of chitinase from Rhodothermus marinus. Extremophiles. 2004. DOI: 10.1007/s00792-004-0422-3.

Brigisson, H., Fridjonsson, O., Bahrani-Mougeot, F.K., Hreggvidsson, G.O., Kristjansson J.K., Mattiasson, B.O. A new thermostable a-L-arabinofuranosidase from a novel thermophilic bacterium. Extremophiles. Biotech. Let. 2004; 26(17):1347-1341.

Buckles, E.L., Bahrani-Mougeot, F.K., Molina, A., Lockatell, C.V., Johnson, D.E., Drachenberg, C.B., Burland V., Blattner, F.R., Donnenberg, M.S. Identification and characterization of a novel uropathogenic Escherichia coli-Associated fimbrial Gene cluster. Infect. Immun. 2004; 72(7):3890-3901.

Bahrani-Mougeot, F.K., Buckles, E.L., Lockatell, C.V., Hebel, J.R., Johnson, D.E., Tang, C.M., Donnenberg, M.S. Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract. Mol. Micro. 2002; 45(4):1079-1093.

Bahrani-Mougeot, F.K., Gunther, N.W., IV, Donnenberg, M.S., Mobley H.L.T. UropathogenicE. coli. p. 239-68. In Donnenberg M.S., ed. Escherichia coli: Virulence mechanisms of a versatile pathogen. Academic Press (2002)

Brennan MT, Bahrani-Mougeot FK, Fox PC, Kennedy TP, Hopkins S, Boucher RC, Lockhart PB. The Role of Oral Microbial Colonization in Ventilator-Associated Pneumonia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 98(6):665-72.

Brennan, M.T., Coleman, S., Kent, M.L., Lockhart, P.B., Bahrani-Mougeot, F. and Mougeot, J.L. (2005). Gene expression profiling of buccal mucosa specimens from patients with acute myelogenous leukemia exposed to chemotherapy. J. Clin. Oncol. Vol. 23, No. 16S.

Napeñas, JJ, Brennan MT, Bahrani-Mougeot FK, Fox PC, Lockhart PB. Relationship Between Mucositis and Changes in Oral Microflora during Cancer Chemotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 103(1):48-59

Bahrani-Mougeot, FK., Paster BJ, Coleman, S, Barbuto S, Brennan, MT, Noll J, Kennedy, T, Fox PC, Lockhart PB. Molecular analysis of oral and respiratory bacterial species associated with ventilator-associated pneumonia. J Clin Micro.2007;45(5): 1588-1593.

Lockhart PB, Brennan MT, Sasser H, Noll J, Coleman S, Ashar J, Kent ML, Fox PC, Paster BJ, Bahrani-Mougeot FK. Tooth extraction and tooth brushing both produce bacteremia of endocarditis-related pathogens. J Am Coll Cardiol 2007; 49(9 supplA):301A.

Bahrani-Mougeot FK, Paster BJ, Coleman S, Ashar J, Knost, S, Sautter, RL, Lockhart, PB. Identification of oral bacteria in blood cultures by conventional versus molecular methods. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 105 (6): 720-724.

Bahrani-Mougeot FK, Paster BJ, Coleman S, Asher J, Barbuto S, Lockhart PB. Diverse and novel oral bacterial species in blood following dental procedures. J Clin Micro 2008; 46 (6): 2129-2132.

Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK. Bacteremia associated with tooth brushing and dental extraction. Circulation 2008; 117:3118-3125.

Bahrani-Mougeot FK, Thornhill M, Sasser H, Marriott I, Brennan MT, Papagerakis S, Coleman S, Fox PC, Lockhart PB. Systemic host immuno-inflammatory response to dental extractions and periodontitis. Oral Surg Oral Med Ora Pathol Oral Radiol Endod 2008; 106(4):534-41.

Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK. Response to letter by Kaplan Regarding Article,”Bacteremia associated with tooth brushing and dental extraction”. Circulation 2009; 119 (2): e14.

Bahrani-Mougeot FK, Scobey, MW, Sansonetti, PJ. Enteropathogenic infections. In Encyclopedia of Microbiology (Schaechter M ed). Academic Press. Oxford 2009

Lockhart PB, Brennan MT, Thornhill M, Michalowicz B, Noll J, Bahrani-Mougeot FK, Sasser HC. Poor oral hygiene as a risk factor for infective endocarditis-related bacteremia. J Am Dent Assoc 2009; 140: 1238-1244.

Napeñas JJ, Brennan MT, Coleman S, Kent, ML, Noll, J, Frenette G, Fox PC, Mougeot, J-L, Paster BJ, Lockhart PB, and Bahrani-Mougeot FK. (2010) Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: A pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 109: 554-560

Xu, X. D., Zhang, Y. C., Xi, L. V, Bahrani-Mougeot, FK, Zhang, L.Y, et al. (2011) Treatment of major laparoscopic bile duct injury: A long-term follow-up result. The American Surgeon, 77 (12): 1584-1588

Mougeot, J.L., Bahrani-Mougeot F.K., Brennan, M.T., Lockhart, P.B. (2011) Microarray analyses of oral punch-biopsies from AML patients suggest immune deregulation and DNA damage as a likely prerequisite for chemotherapy-induced oral mucositis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 112 (4): 446-452

Bahrani-Mougeot, F. Strader W, Mougeot, J-L, Lovell R. (2012) Incidence of Klebsiella pneumoniae carbapenemase (KPC)-producing multidrug-resistant bacterial infections in a teaching hospital in southeast. American Journal of Infection Control, 40 (5): e65

Mougeot J.L., Mougeot F., Padilla R.J., Brennan M.T. and Lockhart P.B. (2013) Use of archived biopsy specimens to study gene expression in oral mucosa from chemotherapy-treated cancer patients. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology, 115 (5): 630-7.

Hanna, E.M., Hamp, T., McKillop, J.H., Bahrani-Mougeot, F.K., Martinie, J.B, Horton, J.M., Sindram, D., Gharaibeh, R.Z., Fodor, A.A., Iannitti, D.A. (2014) Comparison of culture and molecular techniques for microbial community characterization in infected necrotizing pancreatitis. J. Surg. Res. In Press (Published Online 05-09-2014).

Research Grant Support

Grant Title: Oral Hygiene, Periodontal Disease, and Infective Endocarditis Funding Agency: NIDCR Grant #: R01-DE023375-01A1 Role: Co- Investigator (PI: Peter Lockhart) Project dates: 09-2014 to 08-2019 Grant Title: Fighting Infections with Genomics to Prevent Hospital Transmission Funding Agency: NIH (AHRQ)- R01 Role: Co-Investigator (PI: Mike Dulin, MD) Project dates: 02-2015 to 1-2020 (Pending)

Grant Title: Molecular analysis of bacterial species in an animal model of alcohol induced, infected necrotizing pancreatitis – A pilot study Funding Agency: Education and Research Grant, Atrium Health Role: Co-Investigator Project dates: 2011-2013

Grant Title: Oral mucositis following chemotherapy and radiotherapy in cancer patients at Carolinas Medical Center Funding Agency: Charlotte Freedland Foundation Role: Co- Investigator Project dates: 2009-present

Grant Title: Determination of the microbial etiology of spontaneous bacterial peritonitis using a molecular approach. Funding Agency: American College of Gastroenterology (ACG) (Clinical Research Grant) Role: Principle investigator Project dates: 2008-2010

Grant Title: Microbial etiology of spontaneous bacterial peritonitis in patients with advanced liver disease. Funding Agency: Atrium Health (Education and Research Grant) Role: Principal Investigator Project dates: 2008-2010

Grant Title: Determining the cause of oral mucositis following chemotherapy for cancer: Molecular analysis of a unique archive of oral mucosal tissues from cancer patients who underwent chemotherapy Funding Agency: Charlotte Freedland Foundation Role: Co- Investigator Project dates: 2008-2009

Grant Title: Viability of clinically important aerobic bacteria using different swab transport systems Funding Agency: Copan Diagnostics Inc. Role: Principal Investigator Project dates: 2007

Grant Title: Determining the cause of oral mucositis following chemotherapy for cancer: Molecular analysis of a unique archive of oral mucosal tissues from cancer patients who underwent chemotherapy Funding Agency: Charlotte Freedland Foundation Role: Co-Investigator Project dates: 2006-2007

Grant Title: Biological validation of differential Gene expression in buccal mucosal specimens of acute myelogenous leukemia patients exposed to chemotherapy Funding Agency: Charlotte-Mecklenburg Health Services Foundation, Inc. Grant #: 204-155 Role: Co-Investigator Project dates: 2006-2007

Grant Title: Immune alterations associated with bacteremia from dental procedures Funding Agency: Charlotte-Mecklenburg Health Services Foundation, Inc. Grant #: 201-287 Role: Co-Investigator Project dates: 2005-2006

Grant Title: Changes in oral flora in patients undergoing cancer chemotherapy Funding Agency: Charlotte-Mecklenburg Health Services Foundation, Inc. Grant #: 201-254 Role: Co-Investigator Project dates: 2004-2008 Grant Title: Role of Oral Bacteria in Ventilator-Associated Pneumonia (VAP) Funding Agency: The Charlotte-Mecklenburg Health Services Foundation, Inc. (#201179) Role: Principal Investigator Project dates: 2003-2007

Grant Title: Relationship between baseline tissue mRNA expression and chemotherapy induced mucositis Funding Agency: Charlotte-Mecklenburg Health Services Foundation, Inc. Grant #: 200-998 Role: Co-Investigator Project dates: 2002-2005

Grant Title: Bacteremia from Dental Extractions vs. Oral Hygiene Funding Agency: NIH/ NIDCR Grant #: R01-DE13559-01A2 Role: Co- Investigator (PI: Peter Lockhart) Project dates: 05-02 to 04-06

Jean-Luc Mougeot, PhD

Research Director
Translational Genomics
Computational Biology Research
Department of Oral Medicine
Professor and Associate Graduate Faculty, UNC-Charlotte


Prior Positions and Experience

  • 2014- Research Director, Translational Genomics/ Computational Biology Research, Department of Oral Medicine, Carolinas Medical Center (CMC), and Adjunct Professor, UNC-Charlotte, Charlotte, NC
  • 2012-2014 Director, Scientific Development, Department of Therapeutic Research and Development, CMC, and Adjunct Professor, UNC-Charlotte, Charlotte, NC
  • 2002-2012 Senior Scientist, Molecular Biologist, Cannon Research Center (CRC), CMC, and Adjunct Professor, UNC-Charlotte, Charlotte, NC
  • 2002- Consultant, Computational Biology/ Bioinformatics, CMC, Charlotte, NC
  • 2000-2002 Senior Research Scientist/ Director, Protein Expression Core Laboratory, deCODE Genetics, Inc., Reykjavik, Iceland
  • 1998-2000 Senior Research Fellow, Laboratory of Molecular Biology, Medical Research Council (MRC), Cambridge, United Kingdom
  • 1997-1998 Consultant, Biotech Marketing, European Center for Management, Colmar, France, Novartis International AG, Basle, Switzerland, and University of Freiburg, Germany

Education

PhD: 1995, University Louis Pasteur (Strasbourg, France)

Research Interests

Dr. Mougeot has a broad research background in gene regulation and molecular mechanisms of pathogenesis in various diseases affecting plants (e.g., pararetroviral infections) and humans (e.g., ovarian cancer, mucositis, schizophrenia, multiple sclerosis, and amyotrophic lateral sclerosis). In addition, during the recent years, Dr. Mougeot has conducted several genome-wide expression profiling studies and used a diverse array of bioinformatics and computational systems biology tools for data analysis. His expertise in computational biology has led to the design of new research strategies or approaches in functional genomics/ proteomics towards improvement or development of diagnosis, prognosis, and therapy. Dr. Mougeot has recently joined the Department of Oral Medicine to dedicate his efforts to the study of diseases such as cancer therapy-induced oral mucositis, head and neck cancer, Sjogren’s syndrome, and infective endocarditis.

Selected Publications

A. Molecular Virology Research

Retrovirology

-Mougeot J.L., Guidasci T., Wurch T., Lebeurier G. and Mesnard J.M. (1993) Identification of C-terminal amino acid residues of cauliflower mosaic virus open reading frame III protein responsible for its DNA binding activity. Proceedings of the National Academy of Sciences U S A; 90(4): pp1470-3. -Leclerc D., Burri L., Kajava A.V., Mougeot J.L., Hess D., Lustig A., Kleemann G. and Hohn T. (1998) The open reading frame III product of cauliflower mosaic virus forms a tetramer through a N-terminal coiled-coil. Journal of Biological Chemistry; 273(44): pp29015-21.

B. Genome and Transcriptome Computional Biology/ Bioinformatics Research

Cancer/ Oral Mucositis

-Marshburn P.B., Zhang J., Bahrani-Mostafavi Z., Mostafavi B. Z., Mougeot J.L. and Roshon, M. (2003). Estrogen receptor-alpha mRNA variants lacking exon 5 or exon 7 are co-expressed with wild type form during all stages of human endometrial development. American Journal of Obstetrics & Gynecology; 191: pp626-634.

-Mougeot J.L., Bahrani-Mostafavi Z., Vachris J.C., McKinney K.Q., Gurlov S., Naumann R.W., Higgins R.V. and Hall, B.J. (2006) Gene expression profiling of ovarian tissues for determination of molecular pathways reflective of tumorigenesis. Journal of Molecular Biology; 258(1): pp310-329.

-Brennan M.T., Coleman S., Kent M.L., Lockhart P.B., Bahrani-Mougeot F. and Mougeot J.L. (2005). Gene expression profiling of buccal mucosa specimens from patients with acute myelogenous leukemia exposed to chemotherapy. Journal of Clinical Oncology; p23 (16S).-Mougeot J.L., Bahrani-Mougeot F., Lockhart P.B. and Brennan M.T. (2011) Microarray analyses of oral punch-biopsies from AML patients suggest immune deregulation and DNA damage as a likely prerequisite for chemotherapy-induced oral mucositis. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology; 112(4): pp446-52.

-Mougeot J.L., Mougeot F.K. Padilla R.J., Brennan M.T. and Lockhart P.B. (2013) Use of archived biopsy specimens to study gene expression in oral mucosa from chemotherapy-treated cancer patients. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology; May, 115(5): pp630-7.

-Lee J.-G., McKinney K.Q., Mougeot J.L., Bonkovsky H.L. and Hwang, S. (2013) Proteomic strategy for probing complementary lethality of kinase inhibitors against pancreatic cancer (2013). Proteomics; December, 13(23-24): pp3554-62.

Infection Control and Microbiome Metagenomics

-Napeñas J.J., Brennan M.T., Coleman S., Kent M.L., Noll J., Frenette G., Nussbaum M.L., Mougeot J.L., Paster B.J., Lockhart P.B. and Bahrani-Mougeot F.K. (2010). Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology; 10 (4): pp554-60.

-Bahrani-Mougeot F.K., Strader W., Mougeot J.L. and Lovell, R. (2012) Incidence of Klebsiella pneumoniae Carbapenemase (KPC)-producing Multidrug-Resistant Bacterial Infections in a Teaching Hospital in SouthEast. American Journal of Infection Control; 40(5): p65.

-Mougeot J.L., Mougeot F.B., Stevens C.B., Kokaras A.S., Morton D., Brennan M.T., Paster B.J. and Lockhart P.B. (2014) Microbiome Analysis of Subgingival Plaque in Bacteremic Patients. Journal of Dental Research; 93(B).

-Mougeot F.B., Mougeot J.L., Stevens C.B., Kokaras A.S., Morton D., Brennan M.T., Paster B.J. and Lockhart P.B. (2014) Effects of Antibiotic Prophylaxis on Microbial Community of Dental Plaque. Journal of Dental Research; 93(B).

Neurosciences

-Mougeot J.L., Bonkovsky H.L. and Brooks B.R. (2008) Genetic polymorphisms in ALS revisited: a systems biology approach. Amyotrophic Lateral Sclerosis; 9(S1): p97.

-Mougeot J.L., Milazi-Richardson S. and Brooks B.R. (2009) Whole-genome association studies of sporadic amyotrophic lateral sclerosis: are retroelements involved? Trends in Molecular Medicine; 15(4): pp148-58. (Bioinformatics meta-analysis)

-Mougeot J.L., Li Z., Price E.A., Wright F.A. and Brooks B.R. (2011) Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway. BMC Medical Genomics; Epub 4:74.

-Baciu C., Thompson K.J., Mougeot J.L., Brooks B.R. and Weller J.W. (2012) The LO-BaFL method and ALS microarray expression analysis. BMC Bioinformatics; 13:244. doi: 10.1186/1471-2105-13-244.

-Mougeot J.L., Price A.E., Ghosh S., Lutin A.C., Hemendinger R.A., Armstrong III E.J. and Brooks B.R. (2012) Confocal microscopy analysis of altered TDP-43 expression in peripheral blood lymphocytes from ALS patients (2012). Amyotrophic Lateral Sclerosis; 13(S1): pp59-72.

-Mougeot J.L., Ghosh S., Lutin A.C., Price A.E., Hemendinger R.A., Armstrong III E.J. and Brooks B.R. (2012) Confocal microscopy analysis of altered TDP-43 expression in peripheral blood lymphocytes from ALS patients. Annals of Neurology, 137th Annual Meeting of the American Neurological Association; 72(16): S1-S232, A3-A8.

-Niemeier J.P., Mougeot J.L., Hurst B. and Grafton L. (2013) Effects of endogenous reproductive hormones fluctuations in TBI short-term recovery. ACRM 90th Annual Meeting. Archives of Physical Medicine and Rehabilitation; Nov. Issue.

-Perrin P.B., Niemeier J.P., Mougeot J.L., Vannoy C.H., Hirsch M.A., Watts J.A., Rossman W., Grafton L.M., Guerrier T.D., Pershad R., Kingsbury C.A., Bartel S.W. and Whitney M.P. (2014) Measures of Injury Severity and Prediction of Acute Traumatic Brain Injury Outcomes. Journal of Head Trauma Rehabilitation; Feb. 28. [Epub ahead of print]

-Mougeot J.L. and Tcheremissine O. (2014) Systemic molecular biomarkers in the discovery and drug development of novel treatments for schizophrenia: challenges and opportunities. Innovations in Clinical Neuroscience. (Under peer-review).

Orthopedics

-Gruber H.E., Mougeot J.L., Hoelscher G., Ingram J.A. and Hanley E.N. (2007). Microarray analysis of laser capture microdissected-annulus cells from the human intervertebral disc. Spine; 32(11): pp1181-87.

C. Stem cell biology and drug studies

Neural stem cell differentiation

-Milazi-Richardson S., Brooks B.R. and Mougeot J.L. (senior author) (2011). Enrichment of motor neuron-like cell precursor derived from mouse embryonic stem cells by density gradient centrifugation. Acta Neuropharmacologica; 1(1): pp16-25.

Motor neuron cell survival

-Hemendinger R.A., Armstrong III E.J., Persinski R., Todd J., Mougeot J.L., Panov A., Volvovitz F. and Rosenfeld J. (2008). Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death. Neurotoxicity Research; 13: pp49-62.

Research Funding Support

-Research Grant Award from the North Carolina Translational and Clinical Science Research Institute (NC-TRACS) -ALS Foundation Research Fund -Freedland Foundation Cancer Research Grants -Atrium Health Research Grants -Sonia Hanko Wyatt Ovarian Cancer Foundation Grant

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