Research
Carolinas Medical Center has an active neuroscience research program. At present, we have 13 research staff members (2 full time and 2 part-time clinical research nurses, 1 nurse practitioner, 1 research coordinator, 2 data management specialists, 1 scheduler/timekeeper, 3 regulatory specialists and 1 finance adviser). Staff can assist trainees with research proposals, IRB and regulatory matters, data collection and storage, and statistical analysis. Clinical research office space is available at CMC-Main hospital, CMC-Kenilworth clinic and CMC-Edgehill clinic. Lab space is available on the CMC campus at the Cannon Research Center if a trainee is to pursue independent bench research.
Below is a sample of the recent and on-going work from our faculty.
Active Clinical/Research Trials
GW Research LTD: A Long-Term Safety Study to Assess the Potential for Chronic Liver Injury in Participants Treated with Epidiolex Cannabidiol Oral Solution, PI Dr. Yuan Fan.
NSI Epilepsy Database - New Onset Seizure, PI Dr. Rajdeep Singh.
PD Gene-PF Parkinson's Foundation: PD GENEration Genetic Registry, PI Dr. Nicholas Fleming.
COVID-19 Amyotrophic Lateral Sclerosis (ALS) Registry, PI Dr. Urvi Desai.
Healey ALS Platform Trial: Multi-Center, Multi-Regimen Clinical Trial Evaluating the Safety and Efficacy of Investigational Products For The Treatment of ALS, PI Dr. Leo McCluskey.
Atrium Health Foundation WATCH-PAT: A Comparative Assessment of Sleep Disordered Breathing in Nonbulbar ALS by Laboratory-Based Polysomnography (PSG) and Wrist Worn Peripheral Arterial Tonometry-Based Device, PI Dr. Urvi Desai.
Sleep SMART: Sleep for Stroke Management And Recovery Trial, PI Dr. Rahul Karamchandani.
PRECISE: Perfusion Imaging to Identify Posterior Circulation Candidates for Thrombectomy, PRECISE.
CAPTIVA: Comparison of Anti-Coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis, PI Dr. Rahul Karamchandani.
SATURN: Statins Use in Intracerebral Hemorrhage Patients, PI Dr. Rahul Karamchandani.
Peer Reviewed Publications
Yaghi S, Shu L, Mandel DM, Leon Guerrero CR, Henninger N, et al. Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study. Stroke. 2024 Apr;55(4):908-918.
Saba K, Jiang B, Yasin R, Hoyle JC. The Daily Fact Pile: Exploring Mutual Microlearning in Neurology Resident Education. Teach Learn Med. 2024 Mar 12:1-12.
Nawaiseh MB, Yassin AM, Al-Sabbagh MQ, AlNawaiseh A, Zureigat H, Aljbour AlMajali D, Haddadin RR, El-Ghanem M, Abu-Rub M. Abnormal Neurologic Findings in Patients With Sickle Cell Disease Without a History of Major Neurologic Events. Neurol Clin Pract. 2024 Feb;14(1):e200215.
Arrillaga-Romany I, Gardner SL, Odia Y, Aguilera D, Allen JE, Batchelor T, Butowski N, Chen C, Cloughesy T, Cluster A, de Groot J, Dixit KS, Graber JJ, Haggiagi AM, Harrison RA, Kheradpour A, Kilburn LB, Kurz SC, Lu G, MacDonald TJ, Mehta M, Melemed AS, Nghiemphu PL, Ramage SC, Shonka N, Sumrall A, Tarapore RS, Taylor L, Umemura Y, Wen PY. ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma. J Clin Oncol. 2024 Feb 9:JCO2301134.
Bonthius DJ. Lymphocytic choriomeningitis virus injures the developing brain: effects and mechanisms. Pediatr Res. 2024 Jan;95(2):551-557.
Karamchandani RR, Satyanarayana S, Yang H, Strong D, Rhoten JB, Clemente JD, Defilipp G, Patel NM, Bernard JD, Stetler WR, Parish JM, Guzik AK, Wolfe SQ, Helms AM, Macko L, Williams L, Retelski J, Asimos AW. The Charlotte Large artery occlusion Endovascular therapy Outcome Score predicts independent outcome after thrombectomy. J Neuroimaging. 2023 Nov-Dec;33(6):960-967.
Venneti S, Kawakibi AR, Ji S, Waszak SM, Sweha SR, Mota M, Pun M, Deogharkar A, Chung C, Tarapore RS, Ramage S, Chi A, Wen PY, Arrillaga-Romany I, Batchelor TT, Butowski NA, Sumrall A, Shonka N, Harrison RA, de Groot J, Mehta M, Hall MD, Daghistani D, Cloughesy TF, Ellingson BM, Beccaria K, Varlet P, Kim MM, Umemura Y, Garton H, Franson A, Schwartz J, Jain R, Kachman M, Baum H, Burant CF, Mottl SL, Cartaxo RT, John V, Messinger D, Qin T, Peterson E, Sajjakulnukit P, Ravi K, Waugh A, Walling D, Ding Y, Xia Z, Schwendeman A, Hawes D, Yang F, Judkins AR, Wahl D, Lyssiotis CA, de la Nava D, Alonso MM, Eze A, Spitzer J, Schmidt SV, Duchatel RJ, Dun MD, Cain JE, Jiang L, Stopka SA, Baquer G, Regan MS, Filbin MG, Agar NYR, Zhao L, Kumar-Sinha C, Mody R, Chinnaiyan A, Kurokawa R, Pratt D, Yadav VN, Grill J, Kline C, Mueller S, Resnick A, Nazarian J, Allen JE, Odia Y, Gardner SL, Koschmann C. Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. Cancer Discov. 2023 Nov 1;13(11):2370-2393.
Karamchandani RR, Satyanarayana S, Yang H, Rhoten JB, Strong D, Clemente JD, Defilipp G, Patel NM, Bernard JD, Stetler WR, Parish JM, Hines AU, Patel HN, Helms AM, Macko L, Williams L, Retelski J, Guzik AK, Wolfe SQ, Asimos AW. Predictors of devastating functional outcome despite successful basilar thrombectomy. Interv Neuroradiol. 2023 Nov 21:15910199231216516.
Desai U. How I Treat Chronic Inflammatory Demyelinating Polyneuropathy Podcast. Neurol Ther. 2023 Oct;12(5):1409-1417.
Bonthius DJ. Measles Virus and the Central Nervous System: An Update. Semin Pediatr Neurol. 2023 Oct;47:101078.
Lesport Q, Joerger G, Kaminski HJ, Girma H, McNett S, Abu-Rub M, Garbey M. Eye Segmentation Method for Telehealth: Application to the Myasthenia Gravis Physical Examination. Sensors (Basel). 2023 Sep 7;23(18):7744.
Karamchandani RR, Satyanarayana S, Yang H, Rhoten JB, Strong D, Clemente JD, Defilipp G, Patel NM, Bernard J, Stetler WR, Parish JM, Guzik AK, Wolfe SQ, Asimos AW. Predicting severe disability or death in endovascular thrombectomy with large computed tomography perfusion core infarction and limited penumbra. Interv Neuroradiol. 2023 Aug 11:15910199231193466.
Drozdov AA, Arora M, Sheikhy A, Leon Guerrero CR, Taheri MR. Anterior ischemic stroke: Analysis of the multivariable CT-based models for prediction of clinical outcome. J Stroke Cerebrovasc Dis. 2023 Aug;32(8):107242.
Karamchandani RR, Satyanarayana S, Yang H, Rhoten JB, Strong D, Singh S, Clemente JD, Defilipp G, Hazim M, Patel NM, Bernard J, Stetler WR, Parish JM, Blackwell TA, Heit JJ, Albers GW, Saba K, Guzik AK, Wolfe SQ, Asimos AW. The charlotte large artery occlusion endovascular therapy outcome score compares favorably to the critical area perfusion score for prognostication before basilar thrombectomy. J Stroke Cerebrovasc Dis. 2023 Jul;32(7):107147.
Shenoy S, Akberzie W, Landeo-Gutierrez JS, Leon Guerrero CR, Karroum EG. Evaluation of sleep medicine fellowship program websites. J Clin Sleep Med. 2023 Jun 1;19(6):1083-1088.
Darabi S, Xiu J, Samec T, Kesari S, Carrillo J, Aulakh S, Walsh KM, Sengupta S, Sumrall A, Spetzler D, Glantz M, Demeure MJ. Capicua (CIC) mutations in gliomas in association with MAPK activation for exposing a potential therapeutic target. Med Oncol. 2023 Jun 8;40(7):197.
Helms AM, Yang H, Karamchandani RR, Williams L, Singh S, DeFilipp GJ, Asimos AW. A Telestroke Nurse and Neuroradiologist Model for Extended Window Code Stroke Triage. J Neurosci Nurs. 2023 Jun 1;55(3):74-79.
Al Omari O, Ahmed A, Patel D, Jani C, Singh H, Sasson P, AbdelRazek M. Subacute Combined Degeneration Caused by Nitrous Oxide Abuse Mimicking Guillain-Barré Syndrome. Am J Ther. 2023 May 1;30(3):e307-e310.
Jing J, Ge W, Hong S, Fernandes MB, Lin Z, Yang C, An S, Struck AF, Herlopian A, Karakis I, Halford JJ, Ng MC, Johnson EL, Appavu BL, Sarkis RA, Osman G, Kaplan PW, Dhakar MB, Arcot Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider HA, Kim JA, Swisher CB, Gaspard N, Cervenka MC, Rodriguez Ruiz AA, Lee JW, Tabaeizadeh M, Gilmore EJ, Nordstrom K, Yoo JY, Holmes MG, Herman ST, Williams JA, Pathmanathan J, Nascimento FA, Fan Z, Nasiri S, Shafi MM, Cash SS, Hoch DB, Cole AJ, Rosenthal ES, Zafar SF, Sun J, Westover MB. Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation. Neurology. 2023 Apr 25;100(17):e1750-e1762.
Jing J, Ge W, Struck AF, Fernandes MB, Hong S, An S, Fatima S, Herlopian A, Karakis I, Halford JJ, Ng MC, Johnson EL, Appavu BL, Sarkis RA, Osman G, Kaplan PW, Dhakar MB, Jayagopal LA, Sheikh Z, Taraschenko O, Schmitt S, Haider HA, Kim JA, Swisher CB, Gaspard N, Cervenka MC, Rodriguez Ruiz AA, Lee JW, Tabaeizadeh M, Gilmore EJ, Nordstrom K, Yoo JY, Holmes MG, Herman ST, Williams JA, Pathmanathan J, Nascimento FA, Fan Z, Nasiri S, Shafi MM, Cash SS, Hoch DB, Cole AJ, Rosenthal ES, Zafar SF, Sun J, Westover MB. Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs. Neurology. 2023 Apr 25;100(17):e1737-e1749.
Garbey M, Joerger G, Lesport Q, Girma H, McNett S, Abu-Rub M, Kaminski H. A Digital Telehealth System to Compute the Myasthenia Gravis Core Examination Metrics. JMIR Neurotechnol. 2023;2:e43387.
Karamchandani RR, Helms AM, Satyanarayana S, Yang H, Clemente JD, Defilipp G, Strong D, Rhoten JB, Asimos AW. Automated detection of intracranial large vessel occlusions using Viz.ai software: Experience in a large, integrated stroke network. Brain Behav. 2023 Jan;13(1):e2808.
AbdelRazek MA, Tummala S, Khalid F, Tauhid S, Jalkh Y, Khalil S, Hurwitz S, Zurawski J, Bakshi R. Exploring the effect of glatiramer acetate on cerebral gray matter atrophy in multiple sclerosis. J Neurol Sci. 2023 Jan 15;444:120501.
Drozdov AA, Arora M, Leon Guerrero CR, Sparks AD, Reza Taheri M. Appearance of medullary and cortical veins on multiphase CT-angiography in patients with acute ischemic stroke. Clin Neurol Neurosurg. 2023 Jan;224:107523.
Omuro A, Brandes AA, Carpentier AF, Idbaih A, Reardon DA, Cloughesy T, Sumrall A, Baehring J, van den Bent M, Bähr O, Lombardi G, Mulholland P, Tabatabai G, Lassen U, Sepulveda JM, Khasraw M, Vauleon E, Muragaki Y, Di Giacomo AM, Butowski N, Roth P, Qian X, Fu AZ, Liu Y, Potter V, Chalamandaris AG, Tatsuoka K, Lim M, Weller M. Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial. Neuro Oncol. 2023 Jan 5;25(1):123-134.
Lim M, Weller M, Idbaih A, Steinbach J, Finocchiaro G, Raval RR, Ansstas G, Baehring J, Taylor JW, Honnorat J, Petrecca K, De Vos F, Wick A, Sumrall A, Sahebjam S, Mellinghoff IK, Kinoshita M, Roberts M, Slepetis R, Warad D, Leung D, Lee M, Reardon DA, Omuro A. Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter. Neuro Oncol. 2022 Nov 2;24(11):1935-1949.
Frenkel CH, Brickman DS, Trufan SJ, Ward MC, Moeller BJ, Carrizosa DR, Sumrall AL, Milas ZL. Defining targets to improve care delivery for T4 larynx squamous cell carcinoma. Laryngoscope Investig Otolaryngol. 2022 Nov 16;7(6):1849-1856.
Karamchandani RR, Satyanarayana S, Yang H, Defilipp G, Strong D, Rhoten JB, Patel NM, Asimos AW. The Charlotte large artery occlusion endovascular therapy outcome score predicts outcome after basilar artery thrombectomy. J Neuroimaging. 2022 Sep;32(5):860-865.
Vaitkevicius H, Ramsay RE, Swisher CB, Husain AM, Aimetti A, Gasior M. Intravenous ganaxolone for the treatment of refractory status epilepticus: Results from an open-label, dose-finding, phase 2 trial. Epilepsia. 2022 Sep;63(9):2381-2391.
Milas ZL, Neelands B, Trufan SJ, Benbow J, Carrizosa D, Brickman DS, Frenkel CH, Sumrall AL, Sudhakar SM, Ward MC. Survivorship Care Plans Improve the Identification of Post-radiation Hypothyroidism After Head and Neck Cancer Treatment. Anticancer Res. 2022 Sep;42(9):4429-4437.
Kakoullis L, Yalcin A, AbdelRazek MA, Sasson JP, Behlau I. Powassan virus infection presenting as acute encephalitis in a patient from the New England area: a case report. Neurol Sci. 2022 Aug;43(8):5119-5123.
Karamchandani RR, Yang H, Prasad T, Strong D, Rhoten JB, Defilipp G, Clemente J, Stetler WR, Bernard J, Asimos AW. Endovascular Thrombectomy Reduces Risk of Poor Functional Outcomes in Patients Presenting within 0-6 Hours with Large Ischemic Core Volumes on Computed Tomography Perfusion. J Stroke Cerebrovasc Dis. 2022 Aug;31(8):106548.
Statland JM, Campbell C, Desai U, Karam C, Díaz-Manera J, Guptill JT, Korngut L, Genge A, Tawil RN, Elman L, Joyce NC, Wagner KR, Manousakis G, Amato AA, Butterfield RJ, Shieh PB, Wicklund M, Gamez J, Bodkin C, Pestronk A, Weihl CC, Vilchez-Padilla JJ, Johnson NE, Mathews KD, Miller B, Leneus A, Fowler M, van de Rijn M, Attie KM. Randomized phase 2 study of ACE-083, a muscle-promoting agent, in facioscapulohumeral muscular dystrophy. Muscle Nerve. 2022 Jul;66(1):50-62.
Polymeris AA, Meinel TR, Oehler H, Hölscher K, Zietz A, Scheitz JF, Nolte CH, Stretz C, Yaghi S, Stoll S, Wang R, Häusler KG, Hellwig S, Klammer MG, Litmeier S, Leon Guerrero CR, Moeini-Naghani I, Michel P, Strambo D, Salerno A, Bianco G, Cereda C, Uphaus T, Gröschel K, Katan M, Wegener S, Peters N, Engelter ST, Lyrer PA, Bonati LH, Grunder L, Ringleb PA, Fischer U, Kallmünzer B, Purrucker JC, Seiffge DJ. Aetiology, secondary prevention strategies and outcomes of ischaemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation. J Neurol Neurosurg Psychiatry. 2022 Jun;93(6):588-598. doi: 10.1136/jnnp-2021-328391.
Pandey M, Xiu J, Mittal S, Zeng J, Saul M, Kesari S, Azadi A, Newton H, Deniz K, Ladner K, Sumrall A, Korn WM, Lou E. Molecular alterations associated with improved outcome in patients with glioblastoma treated with Tumor-Treating Fields. Neurooncol Adv. 2022 Jun 21;4(1):vdac096.
Thomas FP, Brannagan TH 3rd, Butterfield RJ, Desai U, Habib AA, Herrmann DN, Eichinger KJ, Johnson NE, Karam C, Pestronk A, Quinn C, Shy ME, Statland JM, Subramony SH, Walk D, Stevens-Favorite K, Miller B, Leneus A, Fowler M, van de Rijn M, Attie KM. Randomized Phase 2 Study of ACE-083 in Patients With Charcot-Marie-Tooth Disease. Neurology. 2022 Jun 6;98(23):e2356-e2367.
Todd D, Clapp M, Dains P, Karacay B, Bonthius DJ. Purkinje cell-specific deletion of CREB worsens alcohol-induced cerebellar neuronal losses and motor deficits. Alcohol. 2022 Jun;101:27-35.
Karamchandani RR, Prasad T, Strong D, Rhoten JB, Asimos AW. A tool to improve stroke outcome prediction: The charlotte large artery occlusion endovascular therapy outcome score. J Stroke Cerebrovasc Dis. 2022 May;31(5):106393.
Taha A, Abdelrazek MA, Manalo N, Elsadek R, Morrin SJ, Brodski A, Augustynowiczd A, Mollashahi RS, Shenoy A. Traumatic Rupture of a Skull Base Dermoid Cyst Mimicking Chronic Meningitis. Cureus. 2022 May 17;14(5):e25066.
Parish JM, Rhoten JB, Strong D, Prasad T, Hines A, Bernard JD, Clemente J, Karamchandani R, Asimos AW, Stetler WR. Visualization of the Anterior Temporal Artery as a Predictor of Outcome in Middle Cerebral Artery Occlusion Patients Achieving Successful Recanalization After Transfer. Cureus. 2022 May 20;14(5):e25173.
Prabhu RS, Dhakal R, Piantino M, Bahar N, Meaders KS, Fasola CE, Ward MC, Heinzerling JH, Sumrall AL, Burri SH. Volumetric Modulated Arc Therapy (VMAT) Craniospinal Irradiation (CSI) for Children and Adults: A Practical Guide for Implementation. Pract Radiat Oncol. 2022 Mar-Apr;12(2):e101-e109.
Yaghi S, Shu L, Bakradze E, Salehi Omran S, Giles JA, Amar JY, Henninger N, Elnazeir M, Liberman AL, Moncrieffe K, Lu J, Sharma R, Cheng Y, Zubair AS, Simpkins AN, Li GT, Kung JC, Perez D, Heldner M, Scutelnic A, Seiffge D, Siepen B, Rothstein A, Khazaal O, Do D, Kasab SA, Rahman LA, Mistry EA, Kerrigan D, Lafever H, Nguyen TN, Klein P, Aparicio H, Frontera J, Kuohn L, Agarwal S, Stretz C, Kala N, El Jamal S, Chang A, Cutting S, Xiao H, de Havenon A, Muddasani V, Wu T, Wilson D, Nouh A, Asad SD, Qureshi A, Moore J, Khatri P, Aziz Y, Casteigne B, Khan M, Cheng Y, Mac Grory B, Weiss M, Ryan D, Vedovati MC, Paciaroni M, Siegler JE, Kamen S, Yu S, Leon Guerrero CR, Atallah E, De Marchis GM, Brehm A, Dittrich T, Psychogios M, Alvarado-Dyer R, Kass-Hout T, Prabhakaran S, Honda T, Liebeskind DS, Furie K. Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study. Stroke. 2022 Mar;53(3):728-738.
AbdelRazek MA, Casasola M, Mollashahi R, Brodski A, Morin S, Augustynowicz A, Jassim S, Matiello M, Sloane J. Extended B-cell depletion beyond 6-months in patients receiving ocrelizumab or rituximab for CNS demyelinating disease. Mult Scler Relat Disord. 2022 Mar;59:103505.
Kaleem S, Swisher CB. Utility of Quantitative EEG for Seizure Detection in Adults. J Clin Neurophysiol. 2022 Mar 1;39(3):184-194.
James ML, Troy J, Nowacki N, Komisarow J, Swisher CB, Tucker K, Hatton K, Babi MA, Worrall BB, Andrews C, Woo D, Kranz PG, Lascola C, Maughan M, Laskowitz DT; CATCH Investigators. CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial. Neurocrit Care. 2022 Feb;36(1):216-225.