Research
Carolinas Medical Center has an active neuroscience research program. At present, we have 13 research staff members (2 full time and 2 part-time clinical research nurses, 1 nurse practitioner, 1 research coordinator, 2 data management specialists, 1 scheduler/timekeeper, 3 regulatory specialists and 1 finance adviser). Staff can assist trainees with research proposals, IRB and regulatory matters, data collection and storage, and statistical analysis. Clinical research office space is available at CMC-Main hospital, CMC-Kenilworth clinic and CMC-Edgehill clinic. Lab space is available on the CMC campus at the Cannon Research Center if a trainee is to pursue independent bench research.
Below is a sample of the recent and on-going work from our faculty.
Active Clinical/Research Trials
GW Research LTD: A Long-Term Safety Study to Assess the Potential for Chronic Liver Injury in Participants Treated with Epidiolex Cannabidiol Oral Solution, PI Dr. Yuan Fan.
NSI Epilepsy Database - New Onset Seizure, PI Dr. Rajdeep Singh.
PD Gene-PF Parkinson's Foundation: PD GENEration Genetic Registry, PI Dr. Nicholas Fleming.
COVID-19 Amyotrophic Lateral Sclerosis (ALS) Registry, PI Dr. Urvi Desai.
Healey ALS Platform Trial: Multi-Center, Multi-Regimen Clinical Trial Evaluating the Safety and Efficacy of Investigational Products For The Treatment of ALS, PI Dr. Leo McCluskey.
Atrium Health Foundation WATCH-PAT: A Comparative Assessment of Sleep Disordered Breathing in Nonbulbar ALS by Laboratory-Based Polysomnography (PSG) and Wrist Worn Peripheral Arterial Tonometry-Based Device, PI Dr. Urvi Desai.
Sleep SMART: Sleep for Stroke Management And Recovery Trial, PI Dr. Rahul Karamchandani.
PRECISE: Perfusion Imaging to Identify Posterior Circulation Candidates for Thrombectomy, PRECISE.
CAPTIVA: Comparison of Anti-Coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis, PI Dr. Rahul Karamchandani.
SATURN: Statins Use in Intracerebral Hemorrhage Patients, PI Dr. Rahul Karamchandani.
Peer Reviewed Publications
Karamchandani RR, Yang H, Rhoten JB, Strong D, Satyanarayana S, Asimos AW. Validation of the Charlotte large artery occlusion endovascular therapy outcome score using Viz.ai-derived cerebral blood volume index. Interv Neuroradiol. 2025 Feb;31(1):80-87.
Alfano LN, James MK, Grosfjeld Petersen K, Rudolf K, Vissing J, Augsburger R, Mozaffar T, Jones A, Butler A, Laubscher KM, Mockler SRH, Mathews KD, Iammarino MA, Reash NF, Pietruszewski L, Lowes LP, Strahler T, Wicklund M, Hunn S, Weihl CC, Sasidharan S, Currence M, Statland JM, Stinson N, Holzer M, Leung DG, Lott DJ, Kang PB, Holsten S, Desai U, Johnson NE; GRASP‐LGMD Consortium. Prospective observational study of FKRP-related limb-girdle muscular dystrophy R9: A GRASP consortium study. Ann Clin Transl Neurol. 2025 Feb;12(2):332-344.
Karamchandani RR, Satyanarayana S, Yang H, Strong D, Rhoten J, Clemente J, Defilipp G, Patel NM, Bernard J, Stetler W, Parish JM, Albers GW, Heit JJ, Guzik AK, Wolfe SQ, Hines A, Patel HN, Helms AM, Macko L, Williams L, Retelski J, Asimos AW. Neurological outcomes for patients meeting radiographic criteria for DEFUSE 3 and SELECT2. J Neurointerv Surg. 2025 Jan 26:jnis-2024-021976.
Karamchandani RR, Satyanarayana S, Yang H, Rhoten JB, Strong D, Clemente JD, Defilipp G, Patel NM, Bernard J, Stetler WR, Parish JM, Wolfe SQ, Guzik AK, Asimos AW. Predicting poor functional outcomes for patients with large computed tomography perfusion core infarctions treated with endovascular thrombectomy. PLoS One. 2024 Nov 18;19(11):e0309163.
Yassin A, Al-Kraimeen L, Qarqash A, AbuShukair H, Ababneh O, Al-Aomar S, Abu-Rub M, Alsherbini K. Deep brain stimulation targets in drug-resistant epilepsy: Systematic review and meta-analysis of effectiveness and predictors of response. Seizure. 2024 Nov;122:144-152.
Karamchandani RR, Asimos AW, Strong D, Rhoten JB, Clemente JD, Defilipp G, Bernard JD, Stetler WR, Parish JM, Hines AU, Patel HN, Helms AM, Macko L, Retelski J, Williams L, Guzik AK, Wolfe SQ, Patel NM. Early recanalization after tenecteplase versus alteplase: Experience in a large stroke network. J Stroke Cerebrovasc Dis. 2024 Nov;33(11):107931.
Shu L, Akpokiere F, Mandel DM, Field TS, Leon Guerrero CR, et al. Intravenous Thrombolysis in Patients With Cervical Artery Dissection: A Secondary Analysis of the STOP-CAD Study. Neurology. 2024 Oct 8;103(7):e209843.
Krishna V, Hadley A, Englert D, Fleming N, Walter BL, Hennigs E, Merola A, Heldman DA. Automated Motion Sensor-Based Functional Mapping Improves Deep Brain Stimulation Programming Efficiency. Mov Disord Clin Pract. 2024 Oct;11(10):1308-1310.
Aulakh S, Xiu J, Hinton A, Darabi S, Demeure MJ, Sengupta S, Kesari S, Ashley DM, Sumrall AL, Glantz MJ, Spetzler D. Biological and prognostic relevance of epigenetic regulatory genes in high-grade gliomas. Neurooncol Adv. 2024 Oct 4;6(1):vdae169.
Persing B, Kamboj J, Sumrall A, Hoxie G. Am Soc Clin Oncol Educ Book. Using Federal, State, and Grassroots Advocacy to Effect Change in Cancer Care Delivery and Patient Outcomes in the United States 2024 Jun;44(3):e433416.
Zivadinov R, Bergsland N, Jakimovski D, Weinstock-Guttman B, Lorefice L, Schoonheim MM, Morrow SA, Ann Picone M, Pardo G, Zarif M, Gudesblatt M, Nicholas JA, Smith A, Hunter S, Newman S, AbdelRazek MA, Hoti I, Riolo J, Silva D, Fuchs TA, Dwyer MG, Hb Benedict R. Thalamic atrophy and dysconnectivity are associated with cognitive impairment in a multi-center, clinical routine, real-word study of people with relapsing-remitting multiple sclerosis. Neuroimage Clin. 2024;42:103609.
Yaghi S, Shu L, Mandel DM, Leon Guerrero CR, Henninger N, et al. Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study. Stroke. 2024 Apr;55(4):908-918.
Saba K, Jiang B, Yasin R, Hoyle JC. The Daily Fact Pile: Exploring Mutual Microlearning in Neurology Resident Education. Teach Learn Med. 2024 Mar 12:1-12.
Kobayashi K, Taylor KN, Shahabi H, Krishnan B, Joshi A, Mackow MJ, Feldman L, et al. Effective connectivity relates seizure outcome to electrode placement in responsive neurostimulation. Brain Commun. 2024 Feb 22;6(1):fcae035.
Nawaiseh MB, Yassin AM, Al-Sabbagh MQ, AlNawaiseh A, Zureigat H, Aljbour AlMajali D, Haddadin RR, El-Ghanem M, Abu-Rub M. Abnormal Neurologic Findings in Patients With Sickle Cell Disease Without a History of Major Neurolmohamogic Events. Neurol Clin Pract. 2024 Feb;14(1):e200215.
Arrillaga-Romany I, Gardner SL, Odia Y, Aguilera D, Allen JE, Batchelor T, Butowski N, Chen C, Cloughesy T, Cluster A, de Groot J, Dixit KS, Graber JJ, Haggiagi AM, Harrison RA, Kheradpour A, Kilburn LB, Kurz SC, Lu G, MacDonald TJ, Mehta M, Melemed AS, Nghiemphu PL, Ramage SC, Shonka N, Sumrall A, Tarapore RS, Taylor L, Umemura Y, Wen PY. ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma. J Clin Oncol. 2024 Feb 9:JCO2301134.
Bonthius DJ. Lymphocytic choriomeningitis virus injures the developing brain: effects and mechanisms. Pediatr Res. 2024 Jan;95(2):551-557.
Chordoma: demographics and survival analysis with a focus on racial disparities and the role of surgery, a U.S. population-based study. Ullah A, Kenol GS, Lee KT, Yasinzai AQK, Waheed A, Asif B, Khan I, Sharif H, Khan J, Heneidi S, Karki NR, Tareen TK. Clin Transl Oncol. 2024 Jan;26(1):109-118.
Karamchandani RR, Satyanarayana S, Yang H, Strong D, Rhoten JB, Clemente JD, Defilipp G, Patel NM, Bernard JD, Stetler WR, Parish JM, Guzik AK, Wolfe SQ, Helms AM, Macko L, Williams L, Retelski J, Asimos AW. The Charlotte Large artery occlusion Endovascular therapy Outcome Score predicts independent outcome after thrombectomy. J Neuroimaging. 2023 Nov-Dec;33(6):960-967.
Venneti S, Kawakibi AR, Ji S, Waszak SM, Sweha SR, Mota M, Pun M, Deogharkar A, Chung C, Tarapore RS, Ramage S, Chi A, Wen PY, Arrillaga-Romany I, Batchelor TT, Butowski NA, Sumrall A, Shonka N, Harrison RA, de Groot J, Mehta M, Hall MD, Daghistani D, Cloughesy TF, Ellingson BM, Beccaria K, Varlet P, Kim MM, Umemura Y, Garton H, Franson A, Schwartz J, Jain R, Kachman M, Baum H, Burant CF, Mottl SL, Cartaxo RT, John V, Messinger D, Qin T, Peterson E, Sajjakulnukit P, Ravi K, Waugh A, Walling D, Ding Y, Xia Z, Schwendeman A, Hawes D, Yang F, Judkins AR, Wahl D, Lyssiotis CA, de la Nava D, Alonso MM, Eze A, Spitzer J, Schmidt SV, Duchatel RJ, Dun MD, Cain JE, Jiang L, Stopka SA, Baquer G, Regan MS, Filbin MG, Agar NYR, Zhao L, Kumar-Sinha C, Mody R, Chinnaiyan A, Kurokawa R, Pratt D, Yadav VN, Grill J, Kline C, Mueller S, Resnick A, Nazarian J, Allen JE, Odia Y, Gardner SL, Koschmann C. Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. Cancer Discov. 2023 Nov 1;13(11):2370-2393.
Karamchandani RR, Satyanarayana S, Yang H, Rhoten JB, Strong D, Clemente JD, Defilipp G, Patel NM, Bernard JD, Stetler WR, Parish JM, Hines AU, Patel HN, Helms AM, Macko L, Williams L, Retelski J, Guzik AK, Wolfe SQ, Asimos AW. Predictors of devastating functional outcome despite successful basilar thrombectomy. Interv Neuroradiol. 2023 Nov 21:15910199231216516.
Desai U. How I Treat Chronic Inflammatory Demyelinating Polyneuropathy Podcast. Neurol Ther. 2023 Oct;12(5):1409-1417.
Bonthius DJ. Measles Virus and the Central Nervous System: An Update. Semin Pediatr Neurol. 2023 Oct;47:101078.
Lesport Q, Joerger G, Kaminski HJ, Girma H, McNett S, Abu-Rub M, Garbey M. Eye Segmentation Method for Telehealth: Application to the Myasthenia Gravis Physical Examination. Sensors (Basel). 2023 Sep 7;23(18):7744.
Karamchandani RR, Satyanarayana S, Yang H, Rhoten JB, Strong D, Clemente JD, Defilipp G, Patel NM, Bernard J, Stetler WR, Parish JM, Guzik AK, Wolfe SQ, Asimos AW. Predicting severe disability or death in endovascular thrombectomy with large computed tomography perfusion core infarction and limited penumbra. Interv Neuroradiol. 2023 Aug 11:15910199231193466.
Drozdov AA, Arora M, Sheikhy A, Leon Guerrero CR, Taheri MR. Anterior ischemic stroke: Analysis of the multivariable CT-based models for prediction of clinical outcome. J Stroke Cerebrovasc Dis. 2023 Aug;32(8):107242.
Karamchandani RR, Satyanarayana S, Yang H, Rhoten JB, Strong D, Singh S, Clemente JD, Defilipp G, Hazim M, Patel NM, Bernard J, Stetler WR, Parish JM, Blackwell TA, Heit JJ, Albers GW, Saba K, Guzik AK, Wolfe SQ, Asimos AW. The charlotte large artery occlusion endovascular therapy outcome score compares favorably to the critical area perfusion score for prognostication before basilar thrombectomy. J Stroke Cerebrovasc Dis. 2023 Jul;32(7):107147.
Shenoy S, Akberzie W, Landeo-Gutierrez JS, Leon Guerrero CR, Karroum EG. Evaluation of sleep medicine fellowship program websites. J Clin Sleep Med. 2023 Jun 1;19(6):1083-1088.
Darabi S, Xiu J, Samec T, Kesari S, Carrillo J, Aulakh S, Walsh KM, Sengupta S, Sumrall A, Spetzler D, Glantz M, Demeure MJ. Capicua (CIC) mutations in gliomas in association with MAPK activation for exposing a potential therapeutic target. Med Oncol. 2023 Jun 8;40(7):197.
Helms AM, Yang H, Karamchandani RR, Williams L, Singh S, DeFilipp GJ, Asimos AW. A Telestroke Nurse and Neuroradiologist Model for Extended Window Code Stroke Triage. J Neurosci Nurs. 2023 Jun 1;55(3):74-79.
Echemendia RJ, Burma JS, Bruce JM, Davis GA, Giza CC, Guskiewicz KM, Naidu D, Black AM, Broglio S, Kemp S, Patricios JS, Putukian M, Zemek R, Arango-Lasprilla JC, Bailey CM, Brett BL, Didehbani N, Gioia G, Herring SA, Howell D, Master CL, Valovich McLeod TC, Meehan WP 3rd, Premji Z, Salmon D, van Ierssel J, Bhathela N, et al. Acute evaluation of sport-related concussion and implications for the Sport Concussion Assessment Tool (SCAT6) for adults, adolescents and children: a systematic review. Br J Sports Med. 2023 Jun;57(11):722-735.
Al Omari O, Ahmed A, Patel D, Jani C, Singh H, Sasson P, AbdelRazek M. Subacute Combined Degeneration Caused by Nitrous Oxide Abuse Mimicking Guillain-Barré Syndrome. Am J Ther. 2023 May 1;30(3):e307-e310.
Jing J, Ge W, Hong S, Fernandes MB, Lin Z, Yang C, An S, Struck AF, Herlopian A, Karakis I, Halford JJ, Ng MC, Johnson EL, Appavu BL, Sarkis RA, Osman G, Kaplan PW, Dhakar MB, Arcot Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider HA, Kim JA, Swisher CB, et al. Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation. Neurology. 2023 Apr 25;100(17):e1750-e1762.
Jing J, Ge W, Struck AF, Fernandes MB, Hong S, An S, Fatima S, Herlopian A, Karakis I, Halford JJ, Ng MC, Johnson EL, Appavu BL, Sarkis RA, Osman G, Kaplan PW, Dhakar MB, Jayagopal LA, Sheikh Z, Taraschenko O, Schmitt S, Haider HA, Kim JA, Swisher CB, et al. Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs. Neurology. 2023 Apr 25;100(17):e1737-e1749.
Garbey M, Joerger G, Lesport Q, Girma H, McNett S, Abu-Rub M, Kaminski H. A Digital Telehealth System to Compute the Myasthenia Gravis Core Examination Metrics. JMIR Neurotechnol. 2023;2:e43387.
Karamchandani RR, Helms AM, Satyanarayana S, Yang H, Clemente JD, Defilipp G, Strong D, Rhoten JB, Asimos AW. Automated detection of intracranial large vessel occlusions using Viz.ai software: Experience in a large, integrated stroke network. Brain Behav. 2023 Jan;13(1):e2808.
AbdelRazek MA, Tummala S, Khalid F, Tauhid S, Jalkh Y, Khalil S, HurwitzS, Zurawski J, Bakshi R. Exploring the effect of glatiramer acetate on cerebral gray matter atrophy in multiple sclerosis. J Neurol Sci. 2023 Jan 15;444:120501.
Drozdov AA, Arora M, Leon Guerrero CR, Sparks AD, Reza Taheri M. Appearance of medullary and cortical veins on multiphase CT-angiography in patients with acute ischemic stroke. Clin Neurol Neurosurg. 2023 Jan;224:107523.
Omuro A, Brandes AA, Carpentier AF, Idbaih A, Reardon DA, Cloughesy T, Sumrall A, et al. Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial. Neuro Oncol. 2023 Jan 5;25(1):123-134.